A white boy, aged 11 months, seen by one of us, Feb. 9, 1933, was said by the mother to have had a cold for two days. The past and family histories were essentially negative. Examination showed scattered pneumonic patches throughout the right lung. The temperature was 104.8 F. by rectum. A diagnosis of bronchopneumonia was made and the child was immediately sent to the hospital.
For the first nine days the course of the disease was rather typical and not worthy of comment. Roentgen examination of the chest confirmed the diagnosis of pneumonia. Examinations of the urine had given essentially negative results. On the second day the blood count showed 80 per cent hemoglobin, 4,500,000 red blood cells and 13,700 white blood cells.1 Five days after admission the count was as follows: hemoglobin, 82 per cent; red blood cells, 4,600,000; white blood cells, 8,300; polymorphonuclears, 48 per cent;
Burhyte EL, Gates EW. TOXIC LEUKOPENIA, WITH RECOVERY FOLLOWING INJECTION OF PENTNUCLEOTIDE. JAMA. 1933;100(24):1932. doi:10.1001/jama.1933.27420240001010
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