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Article
June 17, 1933

Die Grundlage der Geschwulstlehre.

JAMA. 1933;100(24):1960. doi:10.1001/jama.1933.02740240056037

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Abstract

This pamphlet is devoted to the development of the theory that the change in the cell which induces cancer is an alteration in the chromosome number, which in turn produces a new race of cells with enhanced growth capacity. The author's measurements of cells in fixed tissues show that in general the nucleus of malignant cells is larger than in normal cells, the nucleoli also, and that the number of chromosomes is increased. He attributes the invasive properties of the cells to their increased growth energy, which is in turn due to the increase in cell dimensions, coupled with hyperplastic changes in the connective tissue stroma, which contribute to the isolation of the rapidly growing neoplastic cell, and hence invasion and ultimate metastasis. There must also be assumed a susceptibility of the organism as a whole, which plays a part in the cell alterations. "Cancer is therefore a problem of

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