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September 15, 2015

Immune Checkpoint Blockade in Cancer Therapy: The 2015 Lasker-DeBakey Clinical Medical Research Award

Author Affiliations
  • 1Department of Immunology and Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas
JAMA. 2015;314(11):1113-1114. doi:10.1001/jama.2015.11929

The 2015 Lasker-DeBakey Clinical Medical Research Award has been presented to James P. Allison, PhD, for pioneering work in enabling T cells of the immune system to attack cancer cells by removing “checkpoints” that normally inhibit T-cell activity. This Viewpoint provides a summary of these discoveries involving regulation of the T-cell response, development of immune checkpoint blockade in cancer therapy, and implications of engaging the immune response as a new modality for cancer treatment.