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June 24, 1933


Author Affiliations

Fellow in Medicine, the Mayo Foundation; ROCHESTER, MINN.
From the Division of Medicine, the Mayo Clinic.

JAMA. 1933;100(25):1987-1993. doi:10.1001/jama.1933.02740250009003

Since the introduction by Bauer1 in 1906 of the galactose test as a method of determining hepatic function, there has been considerable difference of opinion among competent observers as to its practical value. The metabolism of this sugar has been studied intensively, both in this country and abroad, but its application to clinical material received only scanty consideration here until the appearance of the contribution of Shay, Schloss and Bell.2 These authors have given an excellent review of the literature and have outlined the clinical application of the test. They have pointed out the many advantages of galactose as a test substance: (1) its availability in pure form, with freedom from associated gastro-intestinal upsets following its administration; (2) its prompt assimilation from the alimentary canal unchanged and its conversion into glycogen in the liver; (3) the apparent inability of the remainder of the organism to utilize or store