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November 13, 1926


JAMA. 1926;87(20):1649. doi:10.1001/jama.1926.02680200049014

There are emphatic reasons why the metabolism of the carbohydrates is of great concern in the consideration of the chemistry of physiologic processes. As Shaffer1 has pointed out, much the larger part of the energy made use of by man and other animals to warm their bodies and to do muscular work is obtained by the oxidation of glucose and other simple sugars, derived from the digestion of various carbohydrates contained in the food. In the ordinary diets of human beings, from one half to two thirds or even more of the oxidizable foodstuffs are sugars and starches, which after digestion are absorbed from the intestine chiefly in the form of glucose. Fructose and galactose are also absorbed and utilized, though in much smaller quantities. Furthermore, the proteins are presumably potential sources of sugar in the organism; and, on the other hand, the carbohydrates unquestionably may function in promoting