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July 1, 1933

APOMORPHINE AS AN ANTIDOTE TO STRYCHNINE POISONING

JAMA. 1933;101(1):67. doi:10.1001/jama.1933.02740260069030

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Abstract

To the Editor:  —In The Journal, May 20, page 1589, appeared an article by David and Harry Gold, entitled "Apomorphine as an Antidote to Strychnine Poisoning," in which several references were made to a paper by us (The Journal, April 2, 1932, p. 1133). The authors take exception to our experiments showing that apomorphine tends to counteract the effects of strychnine in doses somewhat less than twice the lethal. In our paper we pointed out clearly that apomorphine is not a true antagonist to strychnine and recommended in strychnine poisoning the much more effective and true antidote phenobarbital sodium. But our demonstration of the superiority of the barbiturates to apomorphine and the further demonstration of the ineffectiveness of magnesium sulphate does not alter the validity of our experiments on apomorphine. The barbiturates, as has been fully confirmed, save life, after administration of approximately five times the lethal dose of strychnine;

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