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November 20, 1926


JAMA. 1926;87(21):1744-1745. doi:10.1001/jama.1926.02680210050018

Since the study of rickets has been approached by the path of chemical examination of the affected organism, a number of distinctive factors have been ascertained. It has been made clear that the defective calcification of the bones in rickets is associated with a diminished concentration of the inorganic phosphorus or the calcium of the serum. As has been pointed out,1 certain cases show only a low inorganic phosphorus content, and this is the rule in uncomplicated rickets; other cases show only a low concentration of calcium, the condition usually found when rickets is complicated by tetany; while still others may be associated with diminished concentrations of both these elements. Howland and Kramer2 have assumed that when the product of the calcium and phosphate concentrations in the serum is below a certain figure, active rickets is found, and that when the product rises somewhat above this, healing results,