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November 20, 1926

EXPERIMENTAL SCARLET FEVER AND SUSCEPTIBILITY TESTS

JAMA. 1926;87(21):1746. doi:10.1001/jama.1926.02680210052020
Abstract

Nicolle, Conseil and Durand,1 in Tunis, have recently described the development of scarlet fever—with characteristic fever, angina, glossitis, eruption and desquamation—in a person inoculated with the fourth subculture of a streptococcus isolated from the throat of a scarlet fever patient. This streptococcus was hemolytic, did not ferment mannitol, and produced a toxin demonstrable by skin tests with the culture filtrates. Furthermore, the person inoculated had previously shown susceptibility to scarlet fever toxin by a positive reaction (local erythema and slight rise of temperature) to an intradermal injection of unfiltered urine from the scarlet fever patient. Other persons were tested with the urine, and two who gave positive reactions to filtered urine were later proved susceptible to scarlet fever.

This work, regarded by the authors as confirmatory of the discovery by the Dicks2 that a specific streptococcus is the cause of scarlet fever, emphasizes also the value of their

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