The therapeutic effectiveness of liver and fractions of liver in the treatment of patients with pernicious anemia is well established. Minot, Cohn, Murphy and Lawson,1 and Zerfas2 have demonstrated that the amount of liver extract No. 343 derived from 300 Gm. of whole liver (from 12 to 14 Gm. of the dried powder) is the minimal amount required to produce maximal reticulocyte responses when fed daily by mouth to patients with pernicious anemia in relapse. Sharp,3 Sturgis and Isaacs,4 Conner,5 Wilkinson6 and others have shown that preparations of hog gastric tissue are likewise effective when fed daily in amounts equivalent to from 200 to 300 Gm. of fresh stomach tissue (from 30 to 40 Gm. of desiccated material). Following the work of Castle and his associates,7 Reimann8 reported a marked increase in the potency of liver when it was digested in normal
FOUTS PJ, ZERFAS LG. LIVER-GASTRIC TISSUE PREPARATIONS IN THE TREATMENT OF PERNICIOUS ANEMIA. JAMA. 1933;101(3):188–192. doi:10.1001/jama.1933.02740280008004
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