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Article
July 15, 1933

ACTIVE IMMUNIZATION AGAINST DIPHTHERIA: A RAPID METHOD WITH A SINGLE INJECTION

Author Affiliations

BROOKLYN
From the Department of Pediatrics of the Jewish Hospital of Brooklyn.

JAMA. 1933;101(3):192-193. doi:10.1001/jama.1933.02740280012005
Abstract

The importance of active immunization against diphtheria in the control of this disease has been amply demonstrated. This fact is well illustrated in a recent report on this question published in the weekly health bulletin of the Connecticut State Department of Health. In 1920, previous to the introduction of active immunization, the incidence of diphtheria for each 100,000 inhabitants of that state was 269.4. In the succeeding years, with a single exception, this rate gradually declined until in 1932 it reached the low point of 15.8. It is estimated that, during this period, 31,511 persons in Connecticut had escaped the disease as a result of the preventive measures which had been taken.

Two preparations have previously been employed: (1) slightly toxic mixtures of toxin and antitoxin; and (2) detoxified toxin or toxoid. The latter has practically displaced toxin-antitoxin mixtures, especially in the immunization of young children. Its advantages over the

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