Increasing and uniformly encouraging results, reported in the literature, from the use of malaria and other fever-producing methods in the treatment of syphilis of the central nervous system have led us to try the inoculation of a series of patients with the organism of benign tertian malaria. With few exceptions, the reports so far published must be regarded as essentially preliminary and necessarily of questionable statistical value, since a period of observation of several years is required before final deductions can safely be made. The only justification for recording our own observations at this time is that they may be compared with similar reports of other investigators, and that certain points may be recorded which in our experience we have learned to be of practical value in the management of this type of treatment.
Our modern methods of treatment, in central nervous system syphilis, by the use of the preparations
DRIVER JR, GAMMEL JA, KARNOSH LJ. MALARIA TREATMENT OF CENTRAL NERVOUS SYSTEM SYPHILISPRELMINARY OBSERVATIONS. JAMA. 1926;87(22):1821–1827. doi:10.1001/jama.1926.02680220037009
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