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Comment & Response
September 15, 2015

Amyloid Pathology, Cognitive Impairment, and Alzheimer Disease Risk

Author Affiliations
  • 1Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
  • 2Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
JAMA. 2015;314(11):1177. doi:10.1001/jama.2015.9716

To the Editor In a recent meta-analysis, Ms Jansen and colleagues1 stated that “the presence of SCI [subjective cognitive impairment] in a memory clinic population might not be associated with an increased risk for AD [Alzheimer disease].”

This conclusion cannot be drawn from the cross-sectional design of the included studies. It also contradicts a recent meta-analysis of longitudinal studies,2 which identified an increased dementia risk among patients with SCI.