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To the Editor:
—In The Journal, February 4, page 321, is an article entitled "Epilepsy and Narcolepsy Associated with Hyperinsulinism," by Dr. Searle Harris of Birmingham, Ala. These cases are interesting. Since 1924, when Dr. Harris reported the first case of hyperinsulinism associated with epilepsy, many more cases have been reported in The Journal. Since 1929 I have been studying such cases and have made the following observations: 1. These patients, regardless of the type of epilepsy, show a low blood sugar; especially is this true prior to the epileptic seizure. These blood sugars range from 35 to 65 mg. per hundred cubic centimeters of blood. 2. Low blood sugars mean an anoxemia, alkalosis and edema of the brain, which increases the possibility of convulsions. 3. High blood sugars mean acidosis and dehydration, which decrease the possibility of convulsions. 4. In trying to increase the blood sugar of epileptic patients,
Sandorf M. EPILEPSY ASSOCIATED WITH HYPERINSULINISM. JAMA. 1933;101(4):301–302. doi:10.1001/jama.1933.02740290049034
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