Leukemia may be defined as a systemic disease of unknown etiology in which the normal mechanism for the production of formed blood elements is permanently damaged, with the appearance in the circulating blood of abnormal types of leukocytes. Three common forms of the disease are readily recognized, each of which is a clinical entity with a relatively characteristic blood picture: (1) Chronic myelogenous leukemia, or chronic myeloid leukemia, in which large numbers of granular leukocytes and myelocytes occur in the blood. This is the common form of the disease seen in adults, but is relatively rare in children. It is characterized by a great enlargement of the spleen, muscular weakness and a duration of from one to several years. (2) Chronic lymphoid leukemia, a less frequent type found in older persons and clinically similar to the chronic myelogenous form, but characterized by the presence of very numerous small nongranular mononuclear
COOKE JV. ACUTE LEUKEMIA IN CHILDREN. JAMA. 1933;101(6):432–435. doi:10.1001/jama.1933.02740310016004
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