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December 25, 1926


JAMA. 1926;87(26):2141-2142. doi:10.1001/jama.1926.02680260009003

We attempted to apply the Schulz-Charlton extinction phenomenon to erysipelas, using serum obtained from convalescent erysipelas patients. From 0.5 to 1 cc. was injected intradermally in the central portion of the zone of active inflammation, or in the advancing, raised, red border. Readings were made after six, twelve, eighteen and twenty-four hours. The results of fifty-five cases showed that distinct blanching, such as is produced in scarlet fever with scarlet fever convalescent serum, does not occur in erysipelas with any degree of consistency. Attempts to cause blanching of erysipelas lesions by means of 1 cc. of concentrated scarlet fever antitoxin (Dick) failed in all of ten trials.

Although distinct localized blanching did not result from the inoculation of convalescent erysipelas serum, one was led to conclude that a beneficial effect of some degree followed its introduction into the skin. For example, quite frequently when the injection was made at an