I began experiments with streptococcus vaccine at the suggestion of the late G. N. Gabritchevski1 in January, 1906. At first, vaccination was done only in a hospital for the purpose of studying the clinical picture of the postvaccinal sickness, but it was later transferred to a dispensary and finally, done locally in those villages in which the first cases of scarlet fever had been reported.
The vaccine was prepared by the bacteriologic institute of the Moscow University.
To sum up all the vaccinations carried in the lapse of a year since the end of January, 1906, I may state that there were in all 1,187 vaccinations on 767 persons, 149 of whom were vaccinated thrice; 106, twice, and 528, once.
The method of inoculation employed was as follows: The vaccine, which appeared as a turbid fluid, was shaken before use and injected subcutaneously by means of a Pravaz syringe.
NIKITIN DV. STREPTOCOCCUS VACCINE AS A PREVENTIVE MEASURE FOR SCARLET FEVER. JAMA. 1926;87(26):2143–2145. doi:10.1001/jama.1926.02680260011004
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