Any consideration of the ultimate results following extirpation of cancer of the large bowel, rectosigmoid and rectum which fails to take into account factors that influence favorably or unfavorably the number of survivors after a given term of years is obviously an incomplete one. While one may glibly assert and actually prove by statistics that the prognosis following successful eradication of cancer of the large bowel, rectosigmoid and rectum is more favorable than elsewhere in the alimentary tract, some reasons for these satisfactory end-results should follow in logical sequence. It is my feeling that the most important factor influencing prognosis in cancer of this or other locations is the intrinsic activity of the neoplastic cells, particularly their ability to differentiate or not differentiate from the normal. That this influence is unquestionably affected by modifying conditions present in the majority of instances is, I believe, incontestable. The extrinsic influences, or the
RANKIN FW. THE CURABILITY OF CANCER OF THE COLON, RECTOSIGMOID AND RECTUM: CHAIRMAN'S ADDRESS. JAMA. 1933;101(7):491–495. doi:10.1001/jama.1933.02740320001001
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