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Article
December 25, 1926

HYPOPHYSECTOMY AND REPLACEMENT THERAPYIN RELATION TO BASAL METABOLISM AND SPECIFIC DYNAMIC ACTION IN THE RAT

JAMA. 1926;87(26):2151-2153. doi:10.1001/jama.1926.02680260019007
Abstract

Within the last few years there have appeared several reports 1 to the effect that the specific dynamic action of food is decreased in so-called pituitary disease. No studies of this question appear to have been made on laboratory animals, though there are reports of lowered basal metabolism following surgical removal of or injury to the hypophysis (Benedict and Homans 2 in the dog, Winton and Hogben 3 in the frog). However, much of the work of these investigators is inconclusive on account of the ill defined nature of their experimental material as seen in the light of recent investigations of hypophysial function. The experimental work of Camus and Roussy, 4 Bailey and Bremer 5 and Smith, 6 and the clinical cases of pituitary atrophy, reported by M. Simmonds 7 and others show that a pituitary deficiency does not give rise to obesity. Since most of the clinical cases, aside

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