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August 19, 1933


Author Affiliations

Meridian, Miss.

JAMA. 1933;101(8):622. doi:10.1001/jama.1933.02740330054030

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To the Editor:  —The communication of Dr. Nathan Flaxman (The Journal, July 8, p. 157) appears to have been an attempt at refutation of the points I established in my communication (The Journal, June 10, p. 1882). My purpose was to furnish information based on fact, not to engage in polemics.In my article I admitted and emphasized infectibility by needle but contended that the premises did not justify the conclusion. Dr. Nickum was mistaken in assuming that a person infected with Plasmodium vivax could be reinfected by a needle contaminated with the homologous strain. Furthermore, a threeday period of incubation of tertian malaria in his case is out of the question, since the pyretogenic minimum is accepted as being fifty parasites per cubic millimeter and the total volume of blood in an adult is around five million cubic millimeters. It is possible for a contaminative pyretogenic agent to have

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