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August 26, 1933


JAMA. 1933;101(9):714. doi:10.1001/jama.1933.02740340066012

Not long after the introduction of viosterol, tests made on experimental animals with large doses demonstrated that under certain conditions it can give rise to harm. This knowledge tended for a time to dampen the ardor with which the new vitamin D product was being applied in practical medicine. Before long, however, it was learned that the range between therapeutic and toxic doses is large, so that the danger of overdosage now seems rather remote. Only when the intake of viosterol solutions exceeds the established medicinal dose a thousand times, or by some excess of that approximate magnitude, do the symptoms of disorder clearly manifest themselves. According to a recent compilation,1 it has been found that from 10,000 to 100,000 times the minimum protective dose caused a rapid loss of weight, loss of appetite and decrease in vigor, followed by death in white mice, rats, guineapigs, rabbits, cats and