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August 26, 1933


JAMA. 1933;101(9):721-722. doi:10.1001/jama.1933.02740340073019

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Combined Antidiphtheritic and Antityphoid Vaccination  Vaccination against diphtheria still remains a subject much discussed. The gravity of the disease has increased in France and in other countries, and experience shows that much heavier doses of serum must now be used against it than were used formerly, or a much more potent serum. The same is true of the vaccinations used in its prevention. Ramon's anatoxin has been continually improved by him, so that he has been able to reduce the number of inoculations from four to two, employing, at the same time, much weaker doses, which scarcely ever cause serum reactions. Furthermore, serum reactions can be completely eliminated by the previous injection of a mixture of sodium benzoate and sodium salicylate, as recommended by Vincent. The researches of Crouzon, Loiseau and Laffaille, at the Ecole des infirmièes at the Hôpital de la Salpêtrière, have made known a method of reinforcing

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