The most striking feature of the action of the pancreatic hormone insulin is the immediate lowering of the content of blood sugar that it brings about in both the normal and the diabetic organism. As might be expected, one of the earliest efforts of those engaged in the interpretation of this characteristic action of insulin was directed toward the discovery of the fate of the disappearing carbohydrate. The suspicion that it might be destroyed by some form of glycolysis in the blood itself was soon given up. The possibility that glucose might become altered chemically in some way, so that either it would be more easily metabolized in the organism or would be converted into a different storage compound, was not so easily disposed of. Glycogen formation was always to be thought of; yet the glycogen stores were not regularly found to be augmented. Macleod4 early came to the
THE ACTION OF INSULIN ON CARBOHYDRATES. JAMA. 1927;88(3):173. doi:10.1001/jama.1927.02680290035014
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