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In most instances of hay-fever and asthma in children, there is absence of or merely slight impairment of general health and nutrition, even when the asthmatic state is of almost daily occurrence and of months' or years' duration. In other children there exists, in addition to the physical discomfort, what is apparently a definite clinical state due to the toxemia of constant antigen absorption, the condition being made obvious by the exclusion of other toxic influences, by appropriate laboratory measures, and by the relief of the hay-fever and asthma.
The etiologic factor in these cases has been primarily pollen, with additional feather sensitiveness. Foods have not been a factor in a single instance.
The history of these cases consists of frequent almost nonintermitting so-called colds dating from early infancy, which actually represent the mild type of hay-fever so frequently seen in asthmatic children. Typical severe seasonal hay-fever is unusual. Frequent
KAHN IS. POLLEN TOXEMIA IN CHILDREN. JAMA. 1927;88(4):241–242. doi:10.1001/jama.1927.02680300027008
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