[Skip to Content]
[Skip to Content Landing]
January 22, 1927


JAMA. 1927;88(4):246. doi:10.1001/jama.1927.02680300032013

The development of our knowledge of the origin of the uric acid in the urine has been slow. More than one theory has been abandoned after experimental investigation. This applies, for example, to the view of a previous generation of physiologists that uric acid resulted from a decomposition of simple proteins, in which it might arise as an antecedent of urea. Similarly, the notion of attributing the production of uric acid to a diminished oxidative capacity in the body as a whole may be dismissed. Following Fischer's establishment of the purine structure of uric acid and Kossel's demonstration that purines are disintegration products of nucleoproteins, there came physiologic proofs of the transformation of purine compounds into uric acid in the body.1 A quarter of a century ago the now generally maintained distinction between endogenous and exogenous sources of uric acid was developed. On a diet free from nucleoproteins and