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January 29, 1927


JAMA. 1927;88(5):334-335. doi:10.1001/jama.1927.02680310046018

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The Foam of Mad Dogs  Many vain attempts have been made to discover why the foam in the mouth of mad dogs is such a powerful agent for the transmission of rabic virus. It has been established that the micro-organism of rabies exists only in the nerve tissues and is propagated only by them. Dr. Roux, director of the Pasteur Institute, has announced to the Academy of Sciences that Messieurs Manouelien and Viala have discovered the explanation sought. The tongue of the dog contains large numbers of nerve cells, probably tactile, immediately below the epithelium; in these, in cases of rabies, one finds a large accumulation of Negri bodies. In labioglossopharyngeal paralysis, which is associated with rabies in the dog, the dog clicks his tongue frequently against his teeth or the objects that he bites and bruises the delicate epithelium, which allows the Negri bodies to be distributed throughout the

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