Scarlet fever is a disease subject to wide variations in severity from year to year, and even within seasons. It would seem that the value of streptococcus antitoxic serum1 in the treatment of this condition might best be determined by studying a relatively large number of scarlet fever patients within a short space of time. The patients considered in this report were admitted to the hospital within a six months' period.
Several scarlet fever serums have been used in this hospital during the last year, under rather rigorous conditions, in that only in severe cases, oftentimes apparently hopeless cases, was serum given. The results have been encouraging enough to lead us to institute an accurate, thoroughly controlled test of what appeared to be a reliable serum, and to study its effect on scarlatina of all degrees, from the very mild to the very severe.
The cases include only those
GORDON E. TREATMENT OF SCARLET FEVER WITH STREPTOCOCCUS ANTITOXIN. JAMA. 1927;88(6):382–385. doi:10.1001/jama.1927.02680320018005
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