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September 23, 1933


Author Affiliations

From the Research Department, National Jewish Hospital at Denver.

JAMA. 1933;101(13):982-987. doi:10.1001/jama.1933.02740380018006

An acquaintance with the propagation of tubercle bacilli is the basis for conceptions regarding the pathogenesis of tuberculosis, and this can be expressed simply as the interaction of two components: the one, the tubercle bacillus—the offender—in its ability to persist and to develop in the animal body, and the other component—the host—the cells and fluids of the body which serve to harbor or nourish these bacilli to the point of offensiveness and destructiveness. The paradoxical nature of the pathogenic reactions of tubercle bacilli in different animal species leaves a great deal to be desired in the way of adequate explanation for the present, but suggests the taking of an inventory and revaluation of some of the experiences accumulated during the past few decades, especially concerning the growth and nature of tubercle bacilli under controlled conditions in the culture receptacle.

The fundamental investigations recently concerned with growing tubercle bacilli have resolved