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February 5, 1927

Les pancréatites aigües chirurgicales.

JAMA. 1927;88(6):429. doi:10.1001/jama.1927.02680320065042

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The author analyzes twenty cases of acute pancreatitis and reviews 320 cases from the literature. He classifies them into two chief groups: (1) aseptic, in which there are four types—acute hemorrhagic, edematous, subacute encysted and attenuated; and (2) septic, in which there are two types, gangrenous and suppurative. The clinical picture, the gross pathologic appearance and the microscopic observations are considered in detail. Brocq discusses the vascular theory and the duct theory as to the origin of acute pancreatitis. Numerous experiments were performed on animals by him and his associates, in which acute pancreatitis was successfully produced by the injection of various substances including acids, alkalis, calcium chloride and formaldehyde. Acute pancreatitis was produced experimentally in animals by injecting bile into the pancreatic duct, but only when done during the height of digestion after a full meal. The author found that the duodenal contents, pure intestinal secretion, certain bacteria and

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