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February 12, 1927


Author Affiliations

From the John McCormick Institute for Infectious Diseases.

JAMA. 1927;88(7):459-460. doi:10.1001/jama.1927.02680330011004

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Acute gonorrhea is a generalized inflammation of the mucous membrane of the anterior urethra resulting from the presence of gonococci and the toxic products. The degree of the extension to the posterior urethra or deep into the submucous tissues of the anterior urethra varies directly with the successful control during the early stages of the infection. Various percentages of the extension into the posterior urethra are given by different authors, but it is stated in many text-books on gonorrhea that as high as 75 per cent become posterior. It is doubtful whether such a high proportion become posterior in the present experience of urologists, but in our observations previous to the use of the present method, it seemed highly frequent.

It is generally realized that the organotropic index of a drug must be considered as well as the gonococcidal index in determining the fitness of the drug for local treatment.

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