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Article
February 12, 1927

SYMPATHETIC UVEITIS CAUSED BY THE VIRUS OF HERPES SIMPLEX: REPORT OF EXPERIMENTS

Author Affiliations

OMAHA
From the Department of Ophthalmology, University of Nebraska College of Medicine.

JAMA. 1927;88(7):465-472. doi:10.1001/jama.1927.02680330017007
Abstract

In 1924, von Szily1 reported the results of a series of experiments in which, using material from herpetic lesions of the human cornea, he was able to produce uveitis in the eyes of rabbits, which was transmitted to the other eye. Reasoning that the cause of sympathetic ophthalmia, in view of the almost constant negative results of examinations for the ordinary bacteria, must be of a different nature, he determined to try the effect of an ultramicroscopic virus, which was known to travel by predilection in nerve tissue. The virus of herpes simplex, which was shown by Grüter, Löwenstein and others to cause dendritic ulcers of the cornea and other forms of keratitis, was chosen as possessing the desirable properties. His technic was to inoculate material from a herpetic lesion of the human cornea on the cornea of a rabbit by scarification. After from twenty-four to forty-eight hours, when

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