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Since the suggestion by Ravaut1 in 1920 that sodium thiosulphate be used in the treatment of arsphenamine dermatitis, several reports have appeared in support of the efficacy of the drug in cases of acute erythrodermia following the administration of the organic arsenicals, 2 and in cases of acute mercury poisoning and stomatitis following the use of mercurial salts.3 In none of these has there been a reference to any untoward effect of the thiosulphate other than a transitory febrile disturbance immediately succeeding the intravenous injection, which was thought to have been caused by the failure to use freshly prepared solutions.4
Within the last year two cases of acute arsphenamine dermatitis have come under observation in which the response to sodium thiosulphate treatment has not conformed to that previously observed. In these cases, both of which presented a mild dermatitis of several days' duration, there developed, soon after
FRAZIER CN. PURPURIC VESICULOBULLOUS DERMATITIS: SUBSEQUENT TO INTRAVENOUS INJECTION OF SODIUM THIOSULPHATE: REPORT OF TWO CASES. JAMA. 1927;88(8):537–540. doi:10.1001/jama.1927.02680340009003
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