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Article
September 30, 1933

Phylogenese und Geschwulstentstehung.

JAMA. 1933;101(14):1102. doi:10.1001/jama.1933.02740390060041

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Abstract

The author presents his theoretical views on the etiology of malignant tumors. He opposes the old ontogenic theory of tumor formation, according to which the cells of a malignant tumor are alleged to arise from tissue cells in a comparatively brief period, and favors the phylogenic theory, according to which the malignant cell is a descendant of those early protozoon cells that were responsible for the formation of the first multicellular protozoon organisms. While most of these protozoon cells are later transformed into metazoon cells, some of them retain their protozoon characteristics within the metazoon organism despite a phylogenic development covering perhaps millions of years. Thus the protoplasm of the malignant cell, derived from the earliest period of organic life, is continually being transmitted by way of the germinative substance of the sex cells. In support of his theory the author mentions the morphologically and physiologically similar behavior of protozoon

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