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October 7, 1933


Author Affiliations

Hamilton, Mont. Special Expert in Charge.

JAMA. 1933;101(15):1171. doi:10.1001/jama.1933.02740400057029

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To the Editor:  —The following quotation is from an editorial on Rocky Mountain spotted fever, which appeared in The Journal, August 19. The following comments are made as a reply to the statements made in the editorial:A much neglected phase of this problem has been revived by the work of Zinsser and Ruiz Castaneda on Mexican typhus, a disease that seems quite closely related to Rocky Mountain spotted fever. These workers produced a highly protective serum for the guinea-pig by immunizing a horse to a phenolized suspension of Rickettsia obtained from infected rats previously irradiated with x-rays.The early immune serum studies of Ricketts and Gomez and of Heinemann and Moore and the later ones of Noguchi are then referred to, and the editorial goes on as follows:Despite these encouraging experimental results, there has been no further report of an attempt to increase the potency of immune serum

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