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Article
March 5, 1927

CLINICAL MANIFESTATIONS OF AN ENLARGED THYMUS: DIAGNOSIS AND TREATMENT

Author Affiliations

TORONTO
From the Department of Pediatrics and the Hospital for Sick Children.

JAMA. 1927;88(10):703-706. doi:10.1001/jama.1927.02680360015006
Abstract

It is our intention to present some of our observations and conclusions regarding the diagnosis and treatment of thymic enlargement, without discussing or reviewing the literature. Before presenting our facts it might be wise to consider some of the accepted information regarding this organ.

It may be stated at the outset that in spite of the vast amount of clinical and experimental work that has been done in the last few years, there still remains doubt as to the exact place that the thymus occupies in the bodily economy. Its anatomy is not fixed nor is its physiology clearly determined. It is not even possible at the present moment to state that it belongs to the ductless glands. On one side, it is held that the thymus is essential for growth and development, while the other holds that no developmental changes follow its removal; yet certain diseases of this gland

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