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Article
March 5, 1927

INACTIVATION OF EPINEPHRINE BY CERTAIN COLLOIDAL SILVER PREPARATIONS

Author Affiliations

CLEVELAND
From the Department of Pediatrics, Western Reserve University School of Medicine, and from the Babies and Children's Hospital.

JAMA. 1927;88(10):720-721. doi:10.1001/jama.1927.02680360032012
Abstract

To lessen secretion, usually in acute nasal infections, epinephrine is often used locally, either alone or in combination with various supposedly antiseptic solutions, notably with silver protein preparations. As the majority of the silver preparations in solution liberate silver ions, 1 it would seem that they might inactivate the epinephrine, as epinephrine and other alkaloidal compounds are destroyed by many metallic salts. The investigation reported here was undertaken, therefore, to determine the duration of the action of epinephrine in such silver compounds.

METHOD  Epinephrine decreases nasal secretion, probably by lessening the circulation through local vasoconstriction. As vasoconstriction is readily determined by local blanching of the skin when epinephrine is introduced into the skin by scratching, this method was chosen to determine the epinephrine activity. For nasal application, epinephrine is commonly used in a strength of 1 part of the 1: 1,000 solution to 3 or 4 parts of the silver

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