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March 5, 1927


JAMA. 1927;88(10):740-741. doi:10.1001/jama.1927.02680360052023

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Suprarenal Insufficiency in Grave Diphtheria  A discussion on suprarenal insufficiency in diphtheria developed recently before the Société de pathologie comparée. It has been M. Lereboullet's observation that the suprarenal glands are affected by the diphtheria toxin. In one case out of five at least, lesions of these glands are evident in children who have died from diphtheria. Moreover, symptoms observed in grave diphtheria are often referable to suprarenal insufficiency. The recent researches of M. Lereboullet and his collaborators on hypoglycemia in these patients have established that hypoglycemia is encountered in the majority of cases. The glycemia becomes normal in convalescence. Another argument in favor of suprarenal insufficiency in diphtheria is that the hypoglycemia is similar to that of patients with Addison's disease. Employing this idea in therapeutics, M. Lereboullet reduced the mortality from grave diphtheria 20 per cent by combining suprarenal organotherapy with the ordinary antidiphtheritic serotherapy.

Length of Absence 

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