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October 21, 1933


JAMA. 1933;101(17):1326-1327. doi:10.1001/jama.1933.02740420046019

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Undulant Fever in France  Malta fever has become a disease with ever increasing incidence. Cases are developing today in nearly every part of France. Of particular importance is the article of Ranque and Senez pertaining to the serodiagnosis of the disease. In their laboratory at Marseilles, from 1919 to 1932, they diagnosed 2,800 cases of undulant fever originating in the Provençal region of France. They performed 16,000 Wright seroreactions and conclude that this test constitutes the surest means of diagnosis if it is positive at 1:400 or above, emulsions of cultures of Micrococcus melitensis titered and then sterilized by iodine being employed. If the serodiagnosis is negative on the fifth day of an infection, undulant fever can be ruled out. In the doubtful cases, a second test should be made ten to fifteen days after the first. Undulant fever, which, in this region, showed a rapid increase up to 1929,

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