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March 12, 1927


Author Affiliations

St. Louis. Associate Professor of Experimental Surgery, Washington University School of Medicine, director of Research Laboratories, Barnard Free Skin and Cancer Hospital

JAMA. 1927;88(11):857-858. doi:10.1001/jama.1927.02680370085023

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To the Editor:  —In a recent paper (The Journal, January 15, p. 139) under the title given, Hartman, Bolliger and Doub have shown that chronic interstitial nephritis, quite typical of chronic interstitial nephritis in man, can be produced in dogs by exposing their kidneys to large doses of roentgen rays. These authors have thus produced in an experimental animal a lesion that promises for the first time to allow a more careful study of this disease. One question not discussed by them, or by others discussing their paper, is the significance of their work for a possible classification of chronic interstitial nephritis in terms of other pathologic processes peculiar to man. For a great many years it has been fully appreciated that the pathologic classification of nephritis does not fit the clinical pictures. Chronic interstitial nephritis is not a disease similar to the true chronic infectious processes from which the

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