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Article
March 19, 1927

ACUTE TOXIC CIRRHOSIS: (ACUTE YELLOW ATROPHY)

Author Affiliations

Medical Director and Adjunct Assistant Visiting Physician, Respectively, Gouverneur Hospital NEW YORK

JAMA. 1927;88(12):892-893. doi:10.1001/jama.1927.02680380016005
Abstract

The study of acute degenerative processes of the parenchyma of the liver, or acute cirrhosis, has long constituted a subject of great interest to internists and pathologists. These degenerative foci, as Opie has shown, are due to a combination of toxic (either endogenous or exogenous), and infectious agents, neither of which seems able to produce this condition alone. The destructive lesion begins as a necrosis of the centers of the lobules, and spreads peripherally.1 If the condition is limited, the necrotic cells are removed by the digestive action of the leukocytes, and liver cell regeneration promptly takes place. Provided the greater portion of a lobule is destroyed, little or no regeneration occurs. This process is dependent on the condition of the stroma: if it is not seriously injured, the liver cells can be regenerated. It is rather striking to note the appearance of a liver after the necrotic cells

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