Since transfusion of blood has become an increasingly frequent therapeutic measure, citrated blood has been used considerably more often than has unmodified blood. This is due, largely, to the greater simplicity of technic of the methods employing citrate. It was on this ground that Bernheim1 recommended the sodium citrate method of blood transfusion for use in the medical department of the American Expeditionary Forces in France. Lewisohn,2 reviewing the experience of a decade of the use of citrated blood, rests his strongest argument for the choice of this method on its simplicity and the ease with which a creditable technic may be acquired. There remain, however, a number of physicians who believe that whole coagulable blood is to be preferred to citrated blood. This belief is found recurrently expressed in the literature since the first transfusion with matched bloods, reported by Ottenberg3 in 1908. Thus Brines,4
GICHNER MG. STUDIES OF CITRATED BLOOD: BEHAVIOR OF PLATELETS. JAMA. 1927;88(12):893–895. doi:10.1001/jama.1927.02680380017006
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