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To the Editor:
—Dr. Dabney and associates (The Journal, September 2, p. 771) stress the need of revising the Aschheim-Zondek test in differentiating between hydatidiform mole and threatened or inevitable abortion. The authors correctly quote from Clinical Endocrinology of the Female: "Aschheim obtained a positive pregnancy reaction in a case of hydatidiform mole with one-twelfth the amount of urine usually necessary to secure such a reaction.... In cases of bleeding during the first trimester of pregnancy associated with disproportionate enlargement of the uterus, the patient's urine should be diluted about ten or twelve times with water before it is injected into the test animals."Lack of emphasis on the phrase "the amount of urine usually necessary to secure such a reaction" is responsible for considerable confusion in the use of the Aschheim-Zondek test in the diagnosis of hydatidiform mole and chorio-epithelioma.The amount of urine necessary to produce a pregnancy
Mazer C. THE ASCHHEIM-ZONDEK TEST IN THE DIAGNOSIS OF HYDATIDIFORM MOLE. JAMA. 1933;101(18):1411. doi:10.1001/jama.1933.02740430057032
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