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March 19, 1927


Author Affiliations

From Vanderbilt University Medical Department.

JAMA. 1927;88(12):903-905. doi:10.1001/jama.1927.02680380027011

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As is well known, the treatment of infestation with Trichocephalus dispar and Oxyuris vermicularis leaves much to be desired. They are often unaffected by the specific remedies against ancylostomes, uncinariae, lumbricoids, tenias and other intestinal worms. When Trichocephalus and Oxyuris are localized in the cecum and appendix, any vermifuge taken by mouth will often fail to reach them. For example, Brumpt administered as much as 7 Gm. of thymol to a patient without eliminating Trichocephalus, the ova continuing in the feces for months following the treatment.

Carbon tetrachloride, which has given fair results against the hookworm, is practically valueless against Trichocephalus and Oxyuris, according to my experience in twenty-four cases especially treated with it for the purpose of determining its usefulness. It was also tried in a large number of cases by medical officers of the Spanish army, who reported that it had proved ineffective against Trichocephalus.

For centuries the

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