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Guépin presents an interpretation and clarification of the problem of gonococcic infection based on extensive experience and investigation. He deplores the confused state of knowledge and lack of interest in this infection, the consequences and disastrous end-results of which are frequently minimized. He conceives gonorrhea to be a deep seated infection of the genital tract with a tendency for the gonococcus to persist and multiply in the tissues. There is no definite termination to the infection, which progresses until it exhausts itself. Too much emphasis is placed on the urethral discharge. The abundance or scarcity of urethral secretions is no indication as to the severity or mildness of the infection, in the author's experience. The gonococcus may gradually be altered by the reaction of the tissues. In 1907 Guépin first emphasized the necessity for cultural studies of gonococci in the secretions and since then he has been an ardent advocate
Recherches personnelles pour servir à l'étude de la gonococcie. JAMA. 1933;101(19):1506. doi:10.1001/jama.1933.02740440066038
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