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March 26, 1927


JAMA. 1927;88(13):1005-1006. doi:10.1001/jama.1927.02680390033014

For many years, interest in the therapeutic aspects of blood regeneration after the loss of blood pigment was centered largely in the supply of iron to the body. This element is, of course, conspicuously located in the red blood corpuscles in comparison with other cells of the organism; but from a quantitative standpoint it has long seemed as if overemphasis were being placed on one component of the erythrocytes to the exclusion of other possible precursors of that unique biochemical compound, hemoglobin. The nonferruginous part of this substance is decidedly unlike the constituents of blood-free tissues, and little is known definitely at present about its genesis. Accordingly, there is a growing impression that the study of blood regeneration must take into account not merely the long stressed depletion of the body with respect to iron, but also the possible need of specific organic materials out of which the remainder of