The rapid development of scientific medicine has produced a number of antithetical concepts. Such terms as anatomic, physiologic, bacteriologic, immunologic, hormonal and nervous regulation, genotype and phenotype come readily to mind. Specialistic overenthusiasm and the unlimited accumulation of detailed data have emphasized the divergent and uncoordinated nature of the developments. Any disease, symptom or sign is more or less convincingly "explained" by one of these terms according to the specialty interesting the author. In this chaotic condition, a recent development attempting to synthesize the divergent points of view into a system in which the proper place and correlation is given to all the structural, functional and external factors seems hopeful. Its logical conclusion must be a reconstruction of the entity of a given individual out of its factors of heredity and environmental influences, and to establish his specific chemical, hormonal and nervous formulas, which in their turn condition his responses
CORRELATION OF BIOLOGIC REACTIONS IN HEALTH AND IN DISEASE. JAMA. 1931;96(1):40–41. doi:https://doi.org/10.1001/jama.1931.02720270042014
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