In a recent study1 of the reflex activities of the pyloric sphincter in experimental animals, dogs being used exclusively, various suggestive facts were deduced. Confirmation was made of the known phenomenon that traumatization of abdominal viscera results in a reflex contraction of the pylorus, and at the same time irritation of the parietal peritoneum was found to produce a similar reaction. Furthermore, an effort was made to reproduce the clinical picture of pylorospasm; in other words, to effect a chronic delay in the emptying time of the stomach in the laboratory animals. A preliminary investigation of the emptying time of the stomach in normal dogs had shown this to be 3.4 hours, a large number of examinations having been made to establish this normal figure. Various surgical procedures that might be expected to cause a certain amount of chronic peritoneal irritation were carried out on the abdominal viscera of
HUGHSON W. THE EFFECT OF VAGUS NEUROTOMY ON THE PYLORIC SPHINCTER: AN EXPERIMENTAL STUDY. JAMA. 1927;88(14):1072–1076. doi:10.1001/jama.1927.02680400028010
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