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April 2, 1927


JAMA. 1927;88(14):1093. doi:10.1001/jama.1927.02680400049024

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The Treatment of Diabetes with Synthalin  Dr. Géza Hetényi read a paper on the synthalin treatment of diabetes at the January 27 meeting of the Budapest Royal Medical Society. He stated that synthalin, a synthetic granidine preparation which was introduced into medical practice by Frank, had been used in the clinic of Prof. Alexander Korányi in fourteen cases. In ten of these Hetényi obtained results equal to those of Frank, and in four cases the drug could not be employed on account of its disagreeable by-effects: loss of appetite, epigastric pressure, nausea and vomiting. Occasionally there is albuminuria. Neuropathic, asthenic women were very intolerant of the drug. The advantage of synthalin over insulin would be its cheapness and the fact that it can be administered orally. The by-effects discourage further experimentation and use despite the fact that it renders the patient sugar free within the first few days of its

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