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November 18, 1933


JAMA. 1933;101(21):1644. doi:10.1001/jama.1933.02740460046015

In so-called predisposed or sensitive persons, light, heat or cold may cause not only cutaneous reactions from contact but also more or less serious internal reactions. It is customary nowadays to speak of such reactions as manifestations of physical allergy; that is, a changed reactivity to physical agents.1 There are persons who are sensitive to cold in a peculiar manner. In such cold-sensitive persons exposure to cold atmosphere, cold objects or cold water may cause redness, itching, urticarial eruptions, edema of the skin, pain in the joints, sneezing and swelling of the nasal mucous membrane, and asthmatic symptoms. There may develop headache, dizziness, dyspnea, nausea, palpitation, hemoglobinuria and other serious disturbances of a general nature. In cold-sensitive persons, exposure of large areas of the body to cold, as, for instance, by bathing in cold water or by walking in a cold, moist wind, may give rise to severe "shock,"