Among the methods of identifying and classifying tumors, microscopic examination has for a long time stood preeminent. Until now, in fact, it has been the only method by which substantial accuracy in the identification of neoplasms can be achieved. Without microscopic examination the classification of new growths would be as rudimentary as it was before the development of microscopic pathology. From the standpoint of science in general and medicine in particular, the microscope undoubtedly is one of the most valuable instruments ever invented. If microscopic examination of diseased tissue does not invariably lead to accurate identification of lesions benign or malignant, the fault does not lie with the instrument but with the human observer, the accuracy of whose observations and deductions depends on the quality of the optical system of the microscope, the acuity of his own vision, the range and depth of his knowledge of pathology and other phases
DESJARDINS AU. RADIOTHERAPY AS A METHOD OF IDENTIFYING CERTAIN VARIETIES OF TUMOR. JAMA. 1933;101(22):1705–1710. doi:10.1001/jama.1933.02740470019005
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