In 1923, Chen and Schmidt recommended the use of ephedrine in the treatment of hay fever, asthma and hypotension. Since then, considerable has been written regarding the therapeutic efficacy of the drug but very little mention has been made of the unfavorable effects that it may produce.
Scheer,1 in 1929, was the first to report a case of dermatitis venenata of the nose and upper lip resulting from the local application of ephedrine in oil. Ramirez and Eller2 observed four cases of contact dermatitis due to ephedrine. In 1931, Ayres and Anderson3 reported similar cases following nasal and oral administration of ephedrine, but their cases presented, in addition, generalized scarlatiniform eruptions. Bullen, Frances and Parker,4 in 1932, reported two cases of dermatitis medicamentosa due to ephedrine.
Following is the report of a case of dermatitis venenata due to nasal application of ephedrine inhalant:
REPORT OF CASE
Zeller M. HYPERSENSITIVITY TO EPHEDRINE AND EPHETONINE. JAMA. 1933;101(22):1725–1726. doi:10.1001/jama.1933.27430470001010
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